Nonstop flights from Santa Ana (SNA)
94 nonstop routes from John Wayne Airport, busiest first. Average daily departures over a recent period (AeroDataBox, November 2026).
| Destination | Flights a day | Distance | Airlines |
|---|---|---|---|
| San Francisco SFO | 20 | 598 km | Alaska Airlines, Delta Air Lines, Frontier Airlines |
| Las Vegas LAS | 17 | 365 km | Breeze Airways, Delta Air Lines, Frontier Airlines |
| Phoenix PHX | 15 | 544 km | American Airlines, Frontier Airlines, Southwest Airlines |
| Denver DEN | 12 | 1,360 km | Frontier Airlines, Southwest Airlines, United Airlines |
| Seattle SEA | 12 | 1,576 km | Alaska Airlines, Delta Air Lines |
| Dallas DFW | 10 | 1,935 km | American Airlines, Frontier Airlines |
| San Jose SJC | 9.7 | 550 km | Southwest Airlines |
| Oakland OAK | 8.7 | 597 km | Southwest Airlines |
| Sacramento SMF | 7.6 | 650 km | Southwest Airlines |
| Chicago ORD | 6.6 | 2,772 km | American Airlines, United Airlines |
| Salt Lake City SLC | 6.1 | 947 km | Delta Air Lines |
| Portland PDX | 5.1 | 1,385 km | Alaska Airlines |
| Newark EWR | 3.4 | 3,908 km | United Airlines |
| Houston IAH | 3.4 | 2,163 km | United Airlines |
| Santa Rosa STS | 3.3 | 697 km | Alaska Airlines |
| Atlanta ATL | 3 | 3,081 km | Delta Air Lines |
| New York JFK | 2.3 | 3,941 km | American Airlines, Delta Air Lines |
| Boise BOI | 2 | 1,109 km | Alaska Airlines, Allegiant Air |
| Dallas DAL | 2 | 1,953 km | Southwest Airlines |
| Fresno FAT | 1.7 | 383 km | — |
| Austin AUS | 1.6 | 1,942 km | Southwest Airlines |
| Minneapolis MSP | 1.6 | 2,446 km | Delta Air Lines |
| Burbank BUR | 1.4 | 74 km | — |
| Spokane GEG | 1.4 | 1,551 km | Alaska Airlines |
| Washington IAD | 1.3 | 3,638 km | United Airlines |
| Charlotte CLT | 1.1 | 3,371 km | American Airlines |
| San José del Cabo SJD | 1.1 | 1,414 km | Southwest Airlines |
| Vancouver YVR | 1.1 | 1,780 km | Air Canada |
| Detroit DTW | 1 | 3,148 km | Delta Air Lines |
| Concord CCR | 0.9 | 610 km | — |
| Monterey MRY | 0.9 | 485 km | — |
| Reno RNO | 0.9 | 669 km | — |
| San Diego SAN | 0.9 | 122 km | Southwest Airlines |
| Ogden OGD | 0.7 | 983 km | Breeze Airways |
| Puerto Vallarta PVR | 0.7 | 1,906 km | Southwest Airlines |
| Carlsbad CLD | 0.6 | 82 km | — |
| Everett PAE | 0.6 | 1,625 km | Alaska Airlines |
| Knoxville/Maryville TYS | 0.6 | 3,089 km | — |
| Aspen ASE | 0.4 | 1,160 km | — |
| Mesa AZA | 0.4 | 578 km | Allegiant Air |
| Bellingham BLI | 0.4 | 1,725 km | — |
| Des Moines DSM | 0.4 | 2,295 km | Allegiant Air |
| Eugene EUG | 0.4 | 1,250 km | Allegiant Air |
| Fort Lauderdale FLL | 0.4 | 3,712 km | — |
| Jackson JAC | 0.4 | 1,265 km | — |
| Los Angeles LAX | 0.4 | 58 km | — |
| Muscle Shoals MSL | 0.4 | 2,774 km | — |
| Pasco PSC | 0.4 | 1,404 km | Allegiant Air |
| Redmond RDM | 0.4 | 1,210 km | — |
| Teterboro TEB | 0.4 | 3,916 km | — |
| Calgary YYC | 0.4 | 1,965 km | WestJet |
| Seattle BFI | 0.3 | 1,584 km | — |
| Belfast BFS | 0.3 | 8,235 km | — |
| Nashville BNA | 0.3 | 2,845 km | — |
| Cedar Rapids CID | 0.3 | 2,461 km | — |
| Columbus CMH | 0.3 | 3,170 km | Southwest Airlines |
| Colorado Springs COS | 0.3 | 1,310 km | Allegiant Air |
| White Plains HPN | 0.3 | 3,945 km | — |
| Idaho Falls IDA | 0.3 | 1,204 km | Allegiant Air |
| Medford MFR | 0.3 | 1,061 km | Allegiant Air |
| Mammoth Lakes MMH | 0.3 | 448 km | — |
| Pinellas Park PIE | 0.3 | 3,404 km | — |
| Prescott PRC | 0.3 | 513 km | — |
| Redding RDD | 0.3 | 855 km | — |
| Santa Barbara SBA | 0.3 | 200 km | — |
| San Luis Obispo SBP | 0.3 | 308 km | — |
| San Carlos SQL | 0.3 | 582 km | — |
| Albuquerque ABQ | 0.1 | 1,044 km | — |
| Albany ALB | 0.1 | 3,933 km | — |
| Bakersfield BFL | 0.1 | 224 km | — |
| Denver BJC | 0.1 | 1,328 km | — |
| Boston BOS | 0.1 | 4,162 km | — |
| Bozeman BZN | 0.1 | 1,462 km | — |
| Cleveland CLE | 0.1 | 3,264 km | — |
| West Palm Beach DJT | 0.1 | 3,692 km | — |
| Duluth DLH | 0.1 | 2,606 km | — |
| Kalispell FCA | 0.1 | 1,655 km | — |
| Fort Worth FTW | 0.1 | 1,906 km | — |
| Guadalajara GDL | 0.1 | 2,049 km | — |
| Hayden HDN | 0.1 | 1,209 km | — |
| Houston HOU | 0.1 | 2,180 km | — |
| Lebanon LEB | 0.1 | 4,054 km | — |
| New York LGA | 0.1 | 3,932 km | — |
| Long Beach LGB | 0.1 | 30 km | — |
| Midland MAF | 0.1 | 1,475 km | — |
| Merced MCE | 0.1 | 467 km | — |
| Nassau NAS | 0.1 | 4,005 km | — |
| Ontario ONT | 0.1 | 49 km | — |
| North Bend OTH | 0.1 | 1,216 km | — |
| Palm Springs PSP | 0.1 | 127 km | — |
| Portland PWM | 0.1 | 4,214 km | — |
| Hailey SUN | 0.1 | 1,136 km | — |
| Twin Falls TWF | 0.1 | 1,023 km | — |
| Toronto YYZ | 0.1 | 3,466 km | — |
Routes with fewer than 1 flight a day on average link to the destination airport rather than a route page.