Nonstop flights from Panama City (PTY)
93 nonstop routes from Tocumen International, busiest first. Average daily departures over a recent period (AeroDataBox, November 2026).
| Destination | Flights a day | Distance | Airlines |
|---|---|---|---|
| Bogotá BOG | 11 | 755 km | Copa Airlines, Avianca |
| San José SJO | 11 | 539 km | Copa Airlines |
| Punta Cana PUJ | 9.7 | 1,589 km | Copa Airlines |
| Medellín MDE | 9.3 | 543 km | Copa Airlines |
| Miami MIA | 9.3 | 1,862 km | American Airlines, Copa Airlines |
| Mexico City MEX | 8.3 | 2,411 km | Aeroméxico, Copa Airlines |
| Lima LIM | 8 | 2,359 km | Copa Airlines |
| Orlando MCO | 7.1 | 2,162 km | Copa Airlines |
| Cancún CUN | 6.6 | 1,554 km | Copa Airlines |
| Guatemala City GUA | 6.6 | 1,358 km | Copa Airlines |
| Quito UIO | 6.6 | 1,029 km | Copa Airlines |
| Buenos Aires EZE | 6.4 | 5,351 km | Copa Airlines |
| Guayaquil GYE | 6.3 | 1,250 km | Copa Airlines |
| Cali CLO | 5.4 | 698 km | Copa Airlines |
| Santo Domingo SDQ | 5.3 | 1,477 km | Copa Airlines |
| Cartagena CTG | 5.1 | 451 km | Copa Airlines |
| Santiago SCL | 5.1 | 4,809 km | Copa Airlines |
| São Paulo GRU | 4.7 | 5,086 km | Copa Airlines |
| New York JFK | 4.4 | 3,554 km | Copa Airlines |
| San Salvador (San Luis Talpa) SAL | 4.1 | 1,161 km | Avianca, Copa Airlines |
| Washington IAD | 3.4 | 3,327 km | Copa Airlines |
| Los Angeles LAX | 3.4 | 4,845 km | Copa Airlines |
| David DAV | 3.3 | 344 km | Copa Airlines |
| Rio de Janeiro GIG | 3.3 | 5,295 km | Copa Airlines |
| Cordoba COR | 3 | 4,773 km | Copa Airlines |
| Willemstad CUR | 2.9 | 1,191 km | Copa Airlines |
| Ciudad de la Costa MVD | 2.9 | 5,466 km | Copa Airlines |
| Oranjestad AUA | 2.7 | 1,092 km | Copa Airlines |
| Havana HAV | 2.7 | 1,581 km | Copa Airlines |
| Pereira PEI | 2.7 | 621 km | Copa Airlines |
| Managua MGA | 2.4 | 816 km | Copa Airlines |
| Palmerola XPL | 2.4 | 1,074 km | Copa Airlines |
| Barranquilla BAQ | 2.3 | 543 km | Copa Airlines |
| Houston IAH | 2.3 | 2,856 km | United Airlines |
| San Juan SJU | 2.3 | 1,780 km | Copa Airlines |
| Tampa TPA | 2.3 | 2,128 km | Copa Airlines |
| Maiquetía CCS | 2.1 | 1,368 km | Copa Airlines |
| Valencia VLN | 2.1 | 1,262 km | Copa Airlines |
| Asunción ASU | 2 | 4,490 km | Copa Airlines |
| Chicago ORD | 2 | 3,753 km | Copa Airlines |
| Atlanta ATL | 1.9 | 2,780 km | Copa Airlines, Delta Air Lines |
| Boston BOS | 1.9 | 3,791 km | Copa Airlines |
| Santa Cruz VVI | 1.7 | 3,466 km | Copa Airlines |
| Belo Horizonte CNF | 1.7 | 5,023 km | Copa Airlines |
| Madrid MAD | 1.7 | 8,157 km | Air Europa, Iberia |
| San Pedro Sula SAP | 1.7 | 1,168 km | Copa Airlines |
| San Francisco SFO | 1.7 | 5,344 km | Copa Airlines |
| Guadalajara GDL | 1.6 | 2,864 km | Copa Airlines |
| Monterrey MTY | 1.4 | 2,870 km | Copa Airlines |
| Port of Spain POS | 1.3 | 1,984 km | Copa Airlines |
| Bucaramanga BGA | 1.1 | 716 km | Copa Airlines |
| Newark EWR | 1.1 | 3,553 km | United Airlines |
| Fort Lauderdale FLL | 1.1 | 1,892 km | Copa Airlines |
| Kingston KIN | 1.1 | 1,025 km | Copa Airlines |
| Maracaibo MAR | 1.1 | 855 km | Copa Airlines |
| Montego Bay MBJ | 1.1 | 1,061 km | Copa Airlines |
| Mendoza MDZ | 1.1 | 4,793 km | Copa Airlines |
| Toronto YYZ | 1.1 | 3,848 km | Copa Airlines |
| Amsterdam AMS | 1 | 8,813 km | KLM |
| Georgetown GEO | 1 | 2,345 km | Copa Airlines |
| Istanbul IST | 1 | 10,817 km | Turkish Airlines |
| Nassau NAS | 1 | 1,787 km | Copa Airlines |
| Brasília BSB | 0.9 | 4,437 km | Copa Airlines |
| Paris CDG | 0.9 | 8,661 km | Air France |
| Denver DEN | 0.9 | 4,242 km | Copa Airlines |
| Las Vegas LAS | 0.9 | 4,696 km | Copa Airlines |
| Manaus MAO | 0.9 | 2,531 km | Copa Airlines |
| Porto Alegre POA | 0.9 | 5,289 km | Copa Airlines |
| Rosario ROS | 0.9 | 5,066 km | Copa Airlines |
| San Diego SAN | 0.9 | 4,685 km | Copa Airlines |
| San Andrés ADZ | 0.7 | 466 km | Copa Airlines |
| Austin AUS | 0.7 | 3,020 km | Copa Airlines |
| Bridgetown BGI | 0.7 | 2,215 km | Copa Airlines |
| Barcelona BLA | 0.7 | 1,615 km | Copa Airlines |
| Baltimore BWI | 0.7 | 3,358 km | Copa Airlines |
| Florianópolis FLN | 0.7 | 5,263 km | Copa Airlines |
| Manta MEC | 0.7 | 1,123 km | Copa Airlines |
| Paramaribo PBM | 0.7 | 2,698 km | Copa Airlines |
| Raleigh/Durham RDU | 0.7 | 2,981 km | Copa Airlines |
| Sint Maarten SXM | 0.7 | 2,020 km | Copa Airlines |
| Salvador SSA | 0.6 | 5,151 km | Copa Airlines |
| Barquisimeto BRM | 0.6 | 1,104 km | Copa Airlines |
| Cúcuta CUC | 0.6 | 766 km | Copa Airlines |
| Puerto Plata POP | 0.6 | 1,520 km | Copa Airlines |
| Salta SLA | 0.6 | 4,062 km | Copa Airlines |
| Santa Marta SMR | 0.6 | 608 km | Copa Airlines |
| Calgary YYC | 0.6 | 5,642 km | WestJet |
| Belize City BZE | 0.4 | 1,348 km | Copa Airlines |
| San José del Cabo SJD | 0.4 | 3,587 km | Copa Airlines |
| San Miguel de Tucumán TUC | 0.4 | 4,280 km | Copa Airlines |
| Chiclayo CIX | 0.3 | 1,764 km | Copa Airlines |
| George Town GCM | 0.3 | 1,156 km | — |
| Teterboro TEB | 0.1 | 3,572 km | — |
Routes with fewer than 1 flight a day on average link to the destination airport rather than a route page.