Nonstop flights from Buffalo (BUF)
56 nonstop routes from Buffalo Niagara International Airport, busiest first. Average daily departures over a recent period (AeroDataBox, November 2026).
| Destination | Flights a day | Distance | Airlines |
|---|---|---|---|
| Chicago ORD | 7.9 | 760 km | American Airlines, United Airlines |
| New York LGA | 7.6 | 469 km | American Airlines, Delta Air Lines |
| Boston BOS | 6.9 | 635 km | American Airlines, JetBlue |
| Orlando MCO | 5.7 | 1,630 km | Frontier Airlines, JetBlue, Southwest Airlines |
| Philadelphia PHL | 5.7 | 448 km | American Airlines |
| Baltimore BWI | 5.6 | 453 km | Southwest Airlines |
| Detroit DTW | 5.3 | 387 km | Delta Air Lines |
| Washington IAD | 4.4 | 457 km | United Airlines |
| Atlanta ATL | 4.3 | 1,147 km | Delta Air Lines, Frontier Airlines |
| Washington DCA | 4.3 | 476 km | American Airlines |
| New York JFK | 4.3 | 484 km | JetBlue |
| Charlotte CLT | 4.1 | 880 km | American Airlines |
| Newark EWR | 3.3 | 453 km | United Airlines |
| Chicago MDW | 3.3 | 752 km | Southwest Airlines |
| Tampa TPA | 2.6 | 1,699 km | Southwest Airlines |
| Dallas DFW | 2.4 | 1,949 km | American Airlines |
| Denver DEN | 2.1 | 2,182 km | Southwest Airlines, United Airlines |
| Nashville BNA | 1.6 | 1,018 km | Southwest Airlines |
| Teterboro TEB | 1.3 | 451 km | — |
| Fort Lauderdale FLL | 1.1 | 1,880 km | JetBlue |
| Las Vegas LAS | 1.1 | 3,189 km | Southwest Airlines |
| Phoenix PHX | 1 | 3,070 km | Southwest Airlines |
| Akron CAK | 0.9 | 318 km | — |
| Fort Myers RSW | 0.6 | 1,845 km | JetBlue |
| San Juan SJU | 0.6 | 2,976 km | JetBlue |
| Nantucket ACK | 0.4 | 739 km | — |
| Portsmouth PSM | 0.4 | 643 km | — |
| Raleigh/Durham RDU | 0.4 | 785 km | Frontier Airlines |
| Allentown/Bethlehem ABE | 0.3 | 373 km | — |
| Bedford BED | 0.3 | 610 km | — |
| Binghamton BGM | 0.3 | 240 km | — |
| Cleveland CLE | 0.3 | 308 km | — |
| Martha's Vineyard MVY | 0.3 | 691 km | — |
| Sarasota/Bradenton SRQ | 0.3 | 1,763 km | Southwest Airlines |
| Toronto YYZ | 0.3 | 109 km | Air Canada |
| Alexandria AEX | 0.1 | 1,775 km | — |
| Albany ALB | 0.1 | 402 km | — |
| Hartford BDL | 0.1 | 508 km | — |
| Charlottesville CHO | 0.1 | 534 km | — |
| Dallas DAL | 0.1 | 1,939 km | — |
| West Palm Beach DJT | 0.1 | 1,812 km | — |
| Gulfport GPT | 0.1 | 1,668 km | — |
| White Plains HPN | 0.1 | 464 km | — |
| Niagara Falls IAG | 0.1 | 25 km | — |
| Williamsport IPT | 0.1 | 241 km | — |
| Latrobe LBE | 0.1 | 302 km | — |
| Lebanon LEB | 0.1 | 526 km | — |
| Lexington LEX | 0.1 | 737 km | — |
| Cincinnati LUK | 0.1 | 640 km | — |
| Milwaukee MKE | 0.1 | 746 km | — |
| Portland PWM | 0.1 | 686 km | — |
| Richmond RIC | 0.1 | 616 km | — |
| Rochester ROC | 0.1 | 88 km | — |
| Rochester RST | 0.1 | 1,116 km | — |
| Syracuse SYR | 0.1 | 214 km | — |
| Quebec YQB | 0.1 | 719 km | — |
Routes with fewer than 1 flight a day on average link to the destination airport rather than a route page.